The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
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Publications
ALLHAT Design
Rationale and Design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Davis BR, Cutler JA, Gordon DJ, Furberg CD, Wright JT, Jr, Cushman WC, Grimm RH, LaRosa J, Whelton PK, Perry HM, Alderman MH, Ford CE, Oparil S, Francis C, Proschan M, Pressel S, Black HR, Hawkins CM, for the ALLHAT Research Group.
Am J Hypertension 1996;9:342-360  [PDF]
Baseline Characteristics of the 42,448 high risk hypertensives enrolled in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Grimm RH, Margolis KL, Papademetriou V, Cushman WC, Ford CE, Bettencourt J, Alderman MH, Baslie JN, Black HR, DeQuattro V, Echfeldt J, Hawkins CM, Proschan M, for the ALLHAT Collaborative Research Group.
Hypertension 2001;37:19-27  [PDF]
Baseline Characteristics of the Diabetic Participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Barzilay JI, Jones CL, Davis BR, Basile JN, Goff DC, Ciocon JO, Sweeney ME, Randall OS, for the ALLHAT Collaborative Research Group.
Diabetes Care 2001;24:654-658  [Link to the article]
Characteristics and Lipid Distribution of a Large, High-Risk, Hypertensive Population: The Lipid-Lowering Component of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Papademetriou V, Piller LB, Ford CE, Gordon D, Hartney TJ, Geraci TS, Reison E, Sumner BM, Wong ND, Nwachuku C, Narayan P, Haywood LJ, Habib G, for the ALLHAT Collaborative Research Group.
Journal of Clinical Hypertension 2003;5(6):377-385  [Link to the article]
ALLHAT In the Context of Other Trials
The ANBP2 and ALLHAT: Conflicting or consistent?
Cutler JA.
J Clin Hypertens 2003;5:192-195  [Link to the article]
Related Slide Set: [PowerPoint, 66K] [PDF, 54K]
Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension (Letter to the Editor)
Davis BR, Whelton PK
New England Journal of Medicine 2009;360(11)5:1148-1149  [Link to the article]
BP Control and Differences
Success and Predictors of Blood Pressure Control in Diverse North American Settings: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Cushman WC, Ford CE, Cutler JA, Margolis KL, Davis BR, Grimm RH, Black HR, Hamilton BP, Holland J, Nwachuku C, Papademetriou V, Probstfield J, Wright JT, Alderman MH, Weiss RJ, Piller L, Bettencourt J, Walsh SM, for the ALLHAT Collaborative research Group.
Journal of Clinical Hypertension 2002;4:393-404  [Link to the article]
Related Slide Set:  [PowerPoint, 529K] [PDF, 373K]
Blood Pressure Control in Hispanics in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
Margolis KL, Piller LB, Ford CE, Henriquez MA, Cushman WC, Einhorn PT, Colon PJ, Sr, Vidt DG, Christian R, Wong ND, Wright JT, Jr, Goff DC, Jr; for the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Collaborative Research Group
Hypertension 2007;50:854-861  [Article]
Related Slide Set:  [PowerPoint, 1157K]
Blood pressure control by drug group in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Cushman WC, Ford CE, Einhorn PT, Wright JT Jr, Preston RA, Davis BR, Basile JN, Whelton PK, Weiss RJ, Bastien A, Courtney DL, Hamilton BP, Kirchner K, Louis GT, Retta TM, Vidt DG; ALLHAT Collaborative Research Group.
J Clin Hypertens. 2008;10:751-60  [Link to the article]
Diabetes
Cardiovascular Outcomes Using Doxazosin vs. Chlorthalidone for the Treatment of Hypertension in Older Adults With and Without Glucose Disorders: A Report From the ALLHAT Study.
Barzilay JI, Davis BR, Bettencourt J, Margolis KL, Goff DC, Black H, Habib G, Ellsworth A, Force RW, Wiegmann T, Ciocon JO, Basile JN, for the ALLHAT Collaborative Research Group.
Journal of Clinical Hypertension 2004;6(3):116-125  [Link to the article]
Clinical outcomes in antihypertensive treatment of type 2 diabetes, impaired fasting glucose concentration, and normoglycemia.
Whelton PK, Barzilay J, Cushman WC, Davis BR, Ilamathi E, Kostis JB, Leenen FHH, Louis GT, Morgolis KL, Mathis DE, Moloo J, Nwachuku C, Panebianco D, Parish DC, Pressel S, Simmons DL, Thadani U, for the ALLHAT Collaborative Research Group.
Archives of Internal Medicine 2005;165:1401-1409  [PDF]
Related Slide Set 1: 
[PowerPoint, 2593K] [PDF, 486K]
Fasting Glucose Levels and Incident Diabetes Mellitus in Older Nondiabetic Adults Randomized to Receive 3 Different Classes of Antihypertensive Treatment - A Report From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Barzilay JI, Davis BR, Cutler JA, Pressel SL, Whelton PK, Basile J, Margolis KL, Ong ST, Sadler LS, Summerson J, for the ALLHAT Collaborative Research Group.
Arch Intern Med. 2006;166:2191-2201  [PDF]
Dissemination
Antihypertensive Prescriptions for Newly Treated Patients Before and After the Main Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Results and Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure Guidelines
Muntner P, Krousel-Wood M, Hyre AD, Stanley E, Cushman WC, Cutler JA, Piller LB, Goforth GA, Whelton PK
Hypertension 2009;53:617-623   [PDF]
Getting clinical trial results into practice: design, implementation, and process evaluation of the ALLHAT Dissemination Project.
Bartholomew LK, Cushman WC, Cutler JA, Davis BR, Dawson G, Einhorn PT, Graumlich JF, Piller LB, Pressel S, Roccella EJ, Simpson L, Whelton PK, Williard A, Allhat Collaborative Research Group.
Clin Trials. 2009;6:329-43   [PDF]
Economics/QOL
Cost-effectiveness of Chlorthalidone, Amlodipine, and Lisinopril as First-step Treatment for Patients with Hypertension: An Analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attach Trial (ALLHAT)
Heidenreich PA, Davis BR, Cutler JA, Furberg CD,Lairson DR, Shlipak MG, Nwachuku C, Goldman L.
J Gen Intern Med 23(5):509-16.   [PDF]
Related Slide Set: [PowerPoint, 902K]
Further Explanations of ALLHAT
First results from ALLHAT: Implications for management of urban hypertensives.
Kumar A, Wright JT, Haywood LJ
ABC Digest of Urban Cardiology 2001;8:21-24  
Status of alpha-blocker therapy in the treatment of hypertension: Findings of ALLHAT.
Furberg CD, Cutler JA, Davis BR.
Harrison's Online (http:/harrisonsonline.com/server-java/Arknoid/amed/harrisons/ex_editorieal/edl2856_p01.html) September 19, 2001.  
What ALLHAT tells us about treating high-risk patients with hypertension and hyperlipidemia.
Geraci TS, Geraci SA.
Journal of Cardiovascular Nursing 2003;18(5):389-395.  [PDF]
ALLHAT: Setting the record straight.
Davis BR, Furberg CD, Wright JT, Cutler JA, Whelton P.
Annals of Internal Medicine 2004;141:39-46   [PDF] 
Related Slide Set 1:  [PowerPoint, 44K] [PDF, 51K] Slide Set 2: [PowerPoint, 163K] [PDF, 103K]
ALLHAT Findings Revisited in the Context of Subsequent Analyses, Other Trials, and Meta-analyses
Jackson T. Wright Jr, MD, PhD; Jeffrey L. Probstfield, MD; William C. Cushman, MD; Sara L. Pressel, MS; Jeffrey A. Cutler, MD, MPH; Barry R. Davis, MD, PhD; Paula T. Einhorn, MD, MS; Mahboob Rahman, MD, MS; Paul K. Whelton, MD, MSc; Charles E. Ford, PhD; L. Julian Haywood, MD; Karen L. Margolis, MD, MPH; Suzanne Oparil, MD; Henry R. Black, MD; Michael H. Alderman, MD
Archives of Internal Medicine 2009;169:832-842   [PDF]
GenHAT
Pharmacogenetic approaches to hypertension therapy: design and rationale for the Genetics of Hypertension Associated Treatment (GenHAT) study.
Arnett DK, Boerwinkle E, Davis BR, Eckfeldt J, Ford CE, Black H.
The Pharmacogenomics Journal 2002; 2:309–317  [PDF]
Imputing gene-treatment interactions when the genotype distribution is unknown using case-only and putative placebo analyses - A new method for the Genetics of Hypertension Associated Treatment (GenHAT) Study.
Davis BR, Ford CE, Boerwinkle E, Arnett D, Eckfeldt J, Black H.
Statistics in Medicine 2004; 23:2413-2427.    [PDF]
Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: The Genetics of Hypertension-Associated Treatment (GenHAT) Study.
Arnett DK, Davis BR, Ford CE, Boerwinkle E, Leiendecker-Foster C, Miller MB, Black H, Eckfeldt JH.
Circulation 2005; 111:3374-3383.   [PDF]
Antihypertensive therapy, the a-adducin polymorphism, and cardiovascular disease in high-risk hypertensive persons: the Genetics of Hypertension-Associated Treatment Study.
BR Davis, DK Arnett, E Boerwinkle, CE Ford, C Leiendecker-Foster, MBMiller, H Black, JH Eckfeldt
The Pharmacogenomics Journal 2007; 7:112-122    [PDF]
Absence of an interaction between the angiotensin converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: The Genetics of Hypertension-Associated Treatment (GenHAT) study
Maitland-van der Zee AH, Boerwinkle E, Arnett DK, Davis BR, Leiendecker-Foster C, Miller MB, Klungel OH, Ford CE, and Eckfeldt JH
Am Heart J 2007; 153:54-58  [PDF]
Sex-Specific Effects of AGT-6 and ACE I/D on Pulse Pressure After 6 Months on Antihypertensive Treatment: The GenHAT Study
A I Lynch, D K Arnett, B R Davis, E Boerwinkle, C E Ford, J H Eckfeldt and C Leiendecker-Foster
Annals of Human Genetics 2007; 71:735-745  [PDF]
Pharmacogenetic Association of the NPPA T2238C Genetic Variant With Cardiovascular Disease Outcomes in Patients With Hypertension
A I Lynch, E Boerwinkle, B R Davis, C E Ford, J H Eckfeldt, C Leiendecker-Foster and D K Arnett
JAMA 2008; 299: 296-307  [PDF]
Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study.
Maitland-van der Zee AH, Lynch A, Boerwinkle E, Arnett DK, Davis BR, Leiendecker-Foster C, Ford CE, Eckfeldt JH.
Pharmacogenet Genomics 2008;18:651-6.
Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study.
Lynch AI, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Leiendecker-Foster C, Arnett DK.
Pharmacogenet Genomics 2009;19:415-21.
Heart Failure
Relationship of antihypertensive treatment regimens and change in blood pressure to risk for heart failure in hypertensive patients randomly assigned to doxazosin or chlorthalidone: Further analyses from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
Davis BR, Cutler JA, Furberg CD, Wright JT, Farber MA, Felicetta JV, Stokes JD, for the ALLHAT Collaborative Research Group.
Ann Intern Med 2002;137:313-320  [PDF]
Validation of heart failure events in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants assigned to doxazosin and chlorthalidone.
Piller LB, Davis BR, Cutler JA, Cushman WC, Wright JT, Jr, Williamson JD, Leenen FHH, Einhorn PT, Randall OS, Golden JS, Haywood LJ, for the ALLHAT Collaborative Research Group.
Current Controlled Trials in Cardiovascular Medicine 2002; 3:10-18  [PDF] 
Related Slide Set:  [PowerPoint, 630K] [PDF, 366K]
Role of Diuretics in the Prevention of Heart Failure - The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
Davis BR, Piller LB, Cutler JA, Furberg C, Dunn K, Franklin S, Goff D, Leenen F, Mohiuddin S, Papademetriou V, Proschan M, Ellsworth A, Golden J, Colon P, Crow R for the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Collaborative Research Group.
Circulation. 2006; 113:2201-2210  [PDF] 
Related Slide Set:  [PowerPoint, 1045K] [PDF, 365K]
The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) heart failure Validation Study: Diagnosis and prognosis
Einhorn PT, Davis BR, Massie BM, Cushman WC, Piller LB, Simpson LM, Levy D, Nwachuku CE, Black HR for the ALLHAT Collaborative Research Group.
Am Heart J. 2007; 153:42253  [PDF] 
 
Heart Failure in ALLHAT: Did Blood Pressure Medication at Study Entry Influence Outcome?
Grimm RH, Davis BR, Piller LB, Cutler JA, Margolis KL, Barzilay J, Dart RA, Graumlich JF, Murden RA, Randall OS; for the ALLHAT Collaborative Research Group.
J Clin Hypertens 2009;11:466-474
Heart Failure With Preserved and Reduced Left Ventricular Ejection Fraction in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
Barry R. Davis, John B. Kostis, Lara M. Simpson, Henry R. Black, William C.Cushman, Paula T. Einhorn, Michael A. Farber, Charles E. Ford, Daniel Levy, Barry M. Massie, Shah Nawaz
Circulation 2008;118:2259-67.   [PDF]
Main Results/Implications
Alpha-blockers and congestive heart failure: early termination of an arm of the ALLHAT trial.
Vidt DG.
Cleveland Clinic J Medicine 2000; 67:429-33  
Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group.
JAMA 2000; 283:1967-1975  [PDF] 
Related Slide Set:  [PowerPoint, 2067K] [PDF, 655K]
Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group.
JAMA 2002; 288:2981-2997  [PDF] [Corrected Tab 6, PDF]
Related Slide Sets (ppt):  [#1, 1503K] [#2, 1033K] [#3, 48K] [#4, 45K] [#5, 152K]
Related Slide Sets (pdf): [#1, 3490K] [#2, 1061K] [#3, 52K] [#4, 79K] [#5, 136K]
Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual Care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group.
JAMA 2002; 288: 2998-3007.  [PDF] 
Related Slide Set:  [PowerPoint, 695K] [PDF, 910K]
Table of Trials included in Weighted Meta-Regression Lines in Figure 5  [PDF]
References for Figure 5   [PDF]
Diuretic versus α-blocker as first-step antihypertensive therapy. Final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group.
Hypertension 2003; 42:239-246  [PDF] 
Related Slide Set:  [PowerPoint, 1635K] [PDF, 329K]
Clinical Events in High-Risk Hypertensive Patients Randomly Assigned to Calcium Channel Blocker Versus Angiotensin-Converting Enzyme Inhibitor in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
Frans H.H. Leenen, Chuke E. Nwachuku, Henry R. Black, William C. Cushman, Barry R. Davis, Lara M. Simpson, Michael H. Alderman, Steven A. Atlas, Jan N. Basile, Aloysius B. Cuyjet, Richard Dart, James V. Felicetta, Richard H. Grimm, L. Julian Haywood, Syed Z.A. Jafri, Michael A. Proschan, Udho Thadani, Paul K. Whelton, Jackson T. Wright
Hypertension 2006; 48;374-384  [PDF]
Metabolic Syndrome
Clinical Outcomes by Race in Hypertensive Patients With and Without the Metabolic Syndrome
Jackson T. Wright Jr, MD, PhD; Sonja Harris-Haywood, MD; Sara Pressel, MS; Joshua Barzilay, MD; Charles Baimbridge, MS; Charles J. Bareis, MD; Jan N. Basile, MD; Henry R. Black, MD; Richard Dart, MD; Alok K. Gupta, MD; Bruce P. Hamilton, MD; Paula T. Einhorn, MD, MS; L. Julian Haywood, MD; Syed Z. A. Jafri, MD; Gail T. Louis, RN, BA; Paul K. Whelton, MD, MSc; Cranford L. Scott, MD; Debra L. Simmons, MD; Carol Stanford, MD; Barry R. Davis, MD, PhD
ARCH INTERN MED2008 168(2):207-217.   [PDF]
Metabolic and Clinical Outcomes in Nondiabetic Individuals With the Metabolic Syndrome Assigned toChlorthalidone, Amlodipine, or Lisinopril as Initial Treatment for Hypertension: A report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
HENRY R. BLACK, MD; BARRY DAVIS, MD, PHD; JOSHUA BARZILAY, MD; CHUKE NWACHUKU, MA, MPH, DRPH; CHARLES BAIMBRIDGE, MS; HORIA MARGINEAN, MD, MS; JACKSON T. WRIGHT, JR., MD, PHD; JAN BASILE, MD; NATHAN D. WONG, PHD; PAUL WHELTON, MD, MSC; RICHARD A. DART, MD; UDHO THADANI, MD
DIABETES CARE 2008: 31(2):353-360.   [PDF]
Other
Experimental approaches to determining the choice of first step therapy for patients with hypertension.
Whelton PK, Williamson JD, Louis GT, Davis BR, Cutler JA, for the ALLHAT Research Group.
Clinical and Experimental Hypertension 1996; 18:569-579  [PDF]
Operational aspects of terminating the doxazosin arm of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Pressel SL, Davis BR, Wright JT, Geraci TS, Kingry C, Ford CE, Piller LB, Bettencourt J, Kimmel B, Lusk C, Parks H, Simpson LM, Nwachuku C, Furberg CD, for the ALLHAT Collaborative Research Group.
Controlled Clinical Trials 2001; 22:29-41  [PDF]
The ALLHAT Adherence Survival Kit.
Applied Clinical Trials 2004; 13:40-48  [PDF]
Incidence and Predictors of Angioedema in Elderly Hypertensive Patients at High Risk for Cardiovascular Disease: A Report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Piller LB, Ford CE, Davis BR, Nwachuku CE, Black HR, Oparil S, Retta TM, Probstfield JL.
Journal of Clinical Hypertension 2006:8(9);649-56, CME quiz 657-8.  [PDF]  
Related Slide Set: [PowerPoint, 618K] [PDF, 207K]  [Link to the article]
Management of High Blood Pressure in Clinical Practice: Perceptible Qualitative Differences in Approaches Utilized by Clinicians.
Nwachuku CE, Bastien A, Cutler JA, Grob GM, Margolis KL, Rocella EJ, Pressel S, Davis BR, Caso M, Sheps S, Weber M.
Journal of Clinical Hypertension 2008:10;822-829.  [PDF]  [Link to the article]  
Thiazide-type diuretics and beta-adrenergic blockers as first-line drug treatments for hypertension.
Cutler JA. Davis BR.
Circulation. 2008;117:2691-704; discussion 2705
Outcomes in Demographic Subgroups
Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and lisinopril.
Wright JT, Dunn JK, Cutler JA, Davis BR, Cushman WC, Ford CE, Haywood LJ, Leenen FHH, Margolis KL, Papademetriou V, Probstfield JL, Whelton PK, Habib GB, for the ALLHAT Collaborative Research Group.
JAMA 2005; 293:1595-1608  [PDF]
Related Slide Set: 
[PowerPoint, 589K] [PDF,204K]
Recruitment
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT): Clinical center recruitment experience.
Wright JT, Jr, Cushman WC, Davis BR, Barzilay J, Colon P, Egan D, Lucente T, Nwachuku C, Pressel S, Leenen FHH, Frolkis J, Letterer R, Walsh S, Tobin JN, Deger GE, for the ALLHAT Research Group.
Controlled Clinical Trials 2001; 22:659-673  [PDF]
Participant Recruitment in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Pressel S, Davis BR, Louis GT, Whelton P, Adrogue H, Egan D, Farber M, Payne G, Probstfield J, and Ward H for the ALLHAT Research Group. Controlled Clinical Trials 2001;22:674-686   [PDF]
Renal Status and Outcomes
The prevalence of reduced glomerular filtration rate in older hypertensive patients and its association with cardiovascular disease: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
Rahman M, Brown CD, Coresh J, Davis BR, Eckfeldt JH, Kopyt N, Levey AS, Nwachuku C, Pressel S, Reisin E, Walworth C for the ALLHAT Collaborative Research Group. Arch Intern Med. 2004;164:969-976.   [PDF]
Cardiovascular outcomes in high-risk hypertensive patients stratified by baseline glomerular filtration rate.
Rahman M, Pressel S, Davis B, Nwachuku C, Wright JT Jr., Whelton PK, Barzilay J, Batuman V, Eckfeldt JH, Farber MA, Franklin S, Henriquez M, Kopyt N, Louis GT, Saklayen M, Stanford C, Walworth C, Ward M, Weigmann T for the ALLHAT Collaborative Research Group.
Ann Intern Med. 2006; 144:172-180.   [PDF]
Related Slide Set 1: 
[PowerPoint, 327K] [PDF, 94K]
Renal outcomes in hypertensive patients with impaired renal function.
Rahman M, Cutler J, Davis B, Pressel S, Whelton P, for the ALLHAT Collaborative Research Group.
Archives of Internal Medicine 2005;165:936-946  [PDF]
Related Slide Set 1: 
[PowerPoint, 346K] [PDF, 129K]
Progression of kidney disease in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin versus usual care: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Rahman M, Baimbridge C, Davis BR, Barzilay J, Basile JN, Henriquez MA, Huml A, Kopyt N, Louis GT, Pressel SL, Rosendorff C, Sastrasinh S, Stanford C; ALLHAT Collaborative Research Group.
Am J Kidney Dis. 2008;52:412-24
Comment in: Am J Kidney Dis. 2008;52:391-4.   [PDF]
Coordinating Center for Clinical Trials
Web Comments: allhat@uth.tmc.edu
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