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Publications
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ALLHAT Design
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Rationale and Design for the Antihypertensive and Lipid
Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
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| Davis BR, Cutler JA, Gordon DJ, Furberg CD, Wright JT, Jr, Cushman WC, Grimm RH, LaRosa J, Whelton PK, Perry HM, Alderman MH, Ford CE, Oparil S, Francis C, Proschan M, Pressel S, Black HR, Hawkins CM, for the ALLHAT Research Group.
Am J Hypertension 1996;9:342-360 [PDF] |
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Baseline Characteristics of the 42,448 high risk
hypertensives enrolled in the Antihypertensive and Lipid Lowering Treatment to
Prevent Heart Attack Trial (ALLHAT).
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| Grimm RH, Margolis KL, Papademetriou V, Cushman WC, Ford CE, Bettencourt J, Alderman MH, Baslie JN, Black HR, DeQuattro V, Echfeldt J, Hawkins CM, Proschan M, for the ALLHAT Collaborative Research Group.
Hypertension 2001;37:19-27 [PDF] |
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Baseline Characteristics of the Diabetic Participants in the
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
(ALLHAT).
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| Barzilay JI, Jones CL, Davis BR, Basile JN, Goff DC, Ciocon JO, Sweeney ME, Randall OS, for the ALLHAT Collaborative Research Group.
Diabetes Care 2001;24:654-658 [Link
to the article] |
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Characteristics and Lipid Distribution of a Large,
High-Risk, Hypertensive Population: The Lipid-Lowering Component of the
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
(ALLHAT).
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| Papademetriou V, Piller LB, Ford CE, Gordon D, Hartney TJ, Geraci TS, Reison E, Sumner BM, Wong ND, Nwachuku C, Narayan P, Haywood LJ, Habib G, for the ALLHAT Collaborative Research Group.
Journal of Clinical Hypertension 2003;5(6):377-385 [Link
to the article] |
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ALLHAT In the Context of Other Trials
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Benazepril plus Amlodipine or Hydrochlorothiazide for
Hypertension (Letter to the Editor)
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 | Davis BR, Whelton PK New England Journal of Medicine 2009;360(11)5:1148-1149 [Link
to the article]
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BP Control and Differences
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Success and Predictors of Blood Pressure Control in Diverse
North American Settings: The Antihypertensive and Lipid-Lowering Treatment to
Prevent Heart Attack Trial (ALLHAT).
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 | Cushman WC, Ford CE, Cutler JA, Margolis KL, Davis BR, Grimm RH, Black HR, Hamilton BP, Holland J, Nwachuku C, Papademetriou V, Probstfield J, Wright JT, Alderman MH, Weiss RJ, Piller L, Bettencourt J, Walsh SM, for the ALLHAT Collaborative research Group.
Journal of Clinical Hypertension 2002;4:393-404 [Link
to the article] Related Slide Set:
[PowerPoint, 529K] [PDF, 373K] |
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Blood Pressure Control in Hispanics in the Antihypertensive
and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
|
 | Margolis KL, Piller LB, Ford CE, Henriquez MA, Cushman WC, Einhorn PT, Colon PJ, Sr, Vidt DG, Christian R, Wong ND,
Wright JT, Jr, Goff DC, Jr; for the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Collaborative Research Group
Hypertension 2007;50:854-861 [Article] Related Slide Set:
[PowerPoint, 1157K] |
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Blood pressure control by drug group in the Antihypertensive
and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
|
 | Cushman WC, Ford CE, Einhorn PT, Wright JT Jr, Preston RA, Davis BR, Basile JN,
Whelton PK, Weiss RJ, Bastien A, Courtney DL, Hamilton BP, Kirchner K, Louis GT, Retta TM, Vidt DG; ALLHAT Collaborative Research Group.
J Clin Hypertens. 2008;10:751-60 [Link
to the article] |
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Diabetes
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Cardiovascular Outcomes Using Doxazosin vs. Chlorthalidone
for the Treatment of Hypertension in Older Adults With and Without Glucose
Disorders: A Report From the ALLHAT Study.
|
 | Barzilay JI, Davis BR, Bettencourt J, Margolis KL, Goff DC, Black H, Habib G, Ellsworth A, Force RW, Wiegmann T, Ciocon JO, Basile JN, for the ALLHAT Collaborative Research Group.
Journal of Clinical Hypertension 2004;6(3):116-125 [Link
to the article] |
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Clinical outcomes in antihypertensive treatment of type 2
diabetes, impaired fasting glucose concentration, and normoglycemia.
|
 | Whelton PK, Barzilay J, Cushman WC, Davis BR, Ilamathi E, Kostis JB, Leenen FHH, Louis GT, Morgolis KL, Mathis DE, Moloo J, Nwachuku C, Panebianco D, Parish DC, Pressel S, Simmons DL, Thadani U, for the ALLHAT Collaborative Research Group.
Archives of Internal Medicine 2005;165:1401-1409 [PDF]
Related Slide Set 1: [PowerPoint, 2593K] [PDF, 486K] |
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Fasting Glucose Levels and Incident Diabetes Mellitus in
Older Nondiabetic Adults Randomized to Receive 3 Different Classes of
Antihypertensive Treatment - A Report From the Antihypertensive and
Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
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 | Barzilay JI, Davis BR, Cutler JA, Pressel SL, Whelton PK, Basile J, Margolis KL, Ong ST, Sadler LS, Summerson J, for the ALLHAT Collaborative Research Group.
Arch Intern Med. 2006;166:2191-2201 [PDF]
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Dissemination
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Antihypertensive Prescriptions for Newly Treated Patients
Before and After the Main Antihypertensive and Lipid-Lowering Treatment to
Prevent Heart Attack Trial Results and Seventh Report of the Joint National
Committee on Prevention, Detection, Evaluation, and Treatment of High Blood
Pressure Guidelines
|
 | Muntner P, Krousel-Wood M, Hyre AD, Stanley E, Cushman WC, Cutler JA, Piller LB, Goforth GA, Whelton PK
Hypertension 2009;53:617-623
[PDF] |
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Getting clinical trial results into practice: design,
implementation, and process evaluation of the ALLHAT Dissemination Project.
|
 | Bartholomew LK, Cushman WC, Cutler JA, Davis BR, Dawson G, Einhorn PT, Graumlich JF, Piller LB, Pressel S, Roccella EJ, Simpson L,
Whelton PK, Williard A, Allhat Collaborative Research Group.
Clin Trials. 2009;6:329-43
[PDF] |
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Economics/QOL
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Cost-effectiveness of Chlorthalidone, Amlodipine, and
Lisinopril as First-step Treatment for Patients with Hypertension: An Analysis
of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attach
Trial (ALLHAT)
|
 | Heidenreich PA, Davis BR, Cutler JA, Furberg CD,Lairson DR, Shlipak MG, Nwachuku C, Goldman L.
J Gen Intern Med 23(5):509-16.
[PDF]
Related Slide Set: [PowerPoint,
902K] |
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Further Explanations of ALLHAT
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First results from ALLHAT: Implications for management of
urban hypertensives.
|
 | Kumar A, Wright JT, Haywood LJ ABC Digest of Urban
Cardiology 2001;8:21-24 |
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Status of alpha-blocker therapy in the treatment of
hypertension: Findings of ALLHAT.
|
 | Furberg CD, Cutler JA, Davis BR. Harrison's Online
(http:/harrisonsonline.com/server-java/Arknoid/amed/harrisons/ex_editorieal/edl2856_p01.html) September 19, 2001. |
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What ALLHAT tells us about treating high-risk patients with
hypertension and hyperlipidemia.
|
 | Geraci TS, Geraci SA. Journal of Cardiovascular
Nursing 2003;18(5):389-395. [PDF] |
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ALLHAT Findings Revisited in the Context of Subsequent
Analyses, Other Trials, and Meta-analyses
|
 | Jackson T. Wright Jr, MD, PhD; Jeffrey L. Probstfield, MD; William C. Cushman, MD; Sara L. Pressel, MS;
Jeffrey A. Cutler, MD, MPH; Barry R. Davis, MD, PhD; Paula T. Einhorn, MD, MS; Mahboob Rahman, MD, MS;
Paul K. Whelton, MD, MSc; Charles E. Ford, PhD; L. Julian Haywood, MD; Karen L. Margolis, MD, MPH;
Suzanne Oparil, MD; Henry R. Black, MD; Michael H. Alderman, MD Archives of
Internal Medicine 2009;169:832-842
[PDF] |
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GenHAT
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Pharmacogenetic approaches to hypertension therapy: design
and rationale for the Genetics of Hypertension Associated Treatment (GenHAT)
study.
|
 | Arnett DK, Boerwinkle E, Davis BR, Eckfeldt J, Ford CE, Black H.
The Pharmacogenomics Journal 2002; 2:309–317 [PDF]
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Imputing gene-treatment interactions when the genotype
distribution is unknown using case-only and putative placebo analyses - A new
method for the Genetics of Hypertension Associated Treatment (GenHAT) Study.
|
 | Davis BR, Ford CE, Boerwinkle E, Arnett D, Eckfeldt J, Black H.
Statistics in Medicine 2004; 23:2413-2427.
[PDF]
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Pharmacogenetic association of the angiotensin-converting
enzyme insertion/deletion polymorphism on blood pressure and cardiovascular
risk in relation to antihypertensive treatment: The Genetics of
Hypertension-Associated Treatment (GenHAT) Study.
|
 | Arnett DK, Davis BR, Ford CE, Boerwinkle E, Leiendecker-Foster C, Miller MB, Black H, Eckfeldt JH.
Circulation 2005; 111:3374-3383.
[PDF]
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Antihypertensive therapy, the a-adducin polymorphism, and
cardiovascular disease in high-risk hypertensive persons: the Genetics of
Hypertension-Associated Treatment Study.
|
 | BR Davis, DK Arnett, E Boerwinkle, CE Ford, C Leiendecker-Foster, MBMiller, H Black, JH Eckfeldt
The Pharmacogenomics Journal 2007; 7:112-122
[PDF]
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Absence of an interaction between the angiotensin converting
enzyme insertion-deletion polymorphism and pravastatin on cardiovascular
disease in high-risk hypertensive patients: The Genetics of
Hypertension-Associated Treatment (GenHAT) study
|
 | Maitland-van der Zee AH, Boerwinkle E, Arnett DK, Davis BR, Leiendecker-Foster C, Miller MB, Klungel OH, Ford CE, and Eckfeldt JH
Am Heart J 2007; 153:54-58 [PDF]
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Sex-Specific Effects of AGT-6 and ACE I/D on Pulse Pressure
After 6 Months on Antihypertensive Treatment: The GenHAT Study
|
 | A I Lynch, D K Arnett, B R Davis, E Boerwinkle, C E Ford, J H Eckfeldt and C Leiendecker-Foster
Annals of Human Genetics 2007; 71:735-745 [PDF]
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Pharmacogenetic Association of the NPPA T2238C Genetic
Variant With Cardiovascular Disease Outcomes in Patients With Hypertension
|
 | A I Lynch, E Boerwinkle, B R Davis, C E Ford, J H Eckfeldt, C Leiendecker-Foster and D K Arnett
JAMA 2008; 299: 296-307 [PDF]
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Interactions between the single nucleotide polymorphisms in
the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the
efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease
in high-risk patients of hypertension: the GenHAT study.
|
 | Maitland-van der Zee AH, Lynch A, Boerwinkle E, Arnett DK, Davis BR, Leiendecker-Foster C,
Ford CE, Eckfeldt JH. Pharmacogenet Genomics 2008;18:651-6. |
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Antihypertensive pharmacogenetic effect of fibrinogen-beta
variant -455G>A on cardiovascular disease, end-stage renal disease, and
mortality: the GenHAT study.
|
 | Lynch AI, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Leiendecker-Foster C, Arnett DK.
Pharmacogenet Genomics 2009;19:415-21. |
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Heart Failure
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Relationship of antihypertensive treatment regimens and
change in blood pressure to risk for heart failure in hypertensive patients
randomly assigned to doxazosin or chlorthalidone: Further analyses from the
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
|
 | Davis BR, Cutler JA, Furberg CD, Wright JT, Farber MA, Felicetta JV, Stokes JD, for the ALLHAT Collaborative Research Group.
Ann Intern Med 2002;137:313-320 [PDF] |
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Validation of heart failure events in the Antihypertensive
and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
participants assigned to doxazosin and chlorthalidone.
|
 | Piller LB, Davis BR, Cutler JA, Cushman WC, Wright JT, Jr, Williamson JD, Leenen FHH, Einhorn PT, Randall OS, Golden JS, Haywood LJ, for the ALLHAT Collaborative Research Group.
Current Controlled Trials in Cardiovascular Medicine 2002; 3:10-18 [PDF] Related Slide Set:
[PowerPoint, 630K] [PDF, 366K] |
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Role of Diuretics in the Prevention of Heart Failure - The
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
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 | Davis BR, Piller LB, Cutler JA, Furberg C, Dunn K, Franklin S, Goff D, Leenen F, Mohiuddin S, Papademetriou V, Proschan M, Ellsworth A, Golden J, Colon P, Crow R for the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Collaborative Research Group.
Circulation. 2006; 113:2201-2210 [PDF] Related Slide Set:
[PowerPoint, 1045K] [PDF, 365K] |
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The Antihypertensive and Lipid Lowering Treatment to Prevent
Heart Attack Trial (ALLHAT) heart failure Validation Study: Diagnosis and
prognosis
|
 | Einhorn PT, Davis BR, Massie BM, Cushman WC, Piller LB, Simpson LM, Levy D, Nwachuku CE, Black HR for the ALLHAT Collaborative Research Group.
Am Heart J. 2007; 153:42253 [PDF]
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Heart Failure in ALLHAT: Did Blood Pressure Medication at
Study Entry Influence Outcome?
|
 | Grimm RH, Davis BR, Piller LB, Cutler JA, Margolis KL, Barzilay J, Dart RA, Graumlich JF, Murden RA,
Randall OS; for the ALLHAT Collaborative Research Group.
J Clin Hypertens 2009;11:466-474 |
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Heart Failure With Preserved and Reduced Left Ventricular
Ejection Fraction in the Antihypertensive and Lipid-Lowering Treatment to
Prevent Heart Attack Trial
|
 | Barry R. Davis, John B. Kostis, Lara M. Simpson, Henry R. Black, William C.Cushman,
Paula T. Einhorn, Michael A. Farber, Charles E. Ford, Daniel Levy, Barry M. Massie, Shah Nawaz
Circulation 2008;118:2259-67.
[PDF] |
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Main Results/Implications
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Alpha-blockers and congestive heart failure: early
termination of an arm of the ALLHAT trial.
|
 | Vidt DG. Cleveland Clinic J Medicine 2000; 67:429-33 |
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Major cardiovascular events in hypertensive patients
randomized to doxazosin vs chlorthalidone: the Antihypertensive and
Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
|
 | The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group.
JAMA 2000; 283:1967-1975 [PDF] Related Slide Set:
[PowerPoint, 2067K] [PDF, 655K] |
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Major outcomes in high-risk hypertensive patients randomized
to angiotensin-converting enzyme inhibitor or calcium channel blocker vs
diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart
Attack Trial (ALLHAT).
|
 | The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group.
JAMA 2002; 288:2981-2997 [PDF] [Corrected
Tab 6, PDF] Related Slide Sets (ppt):
[#1, 1503K] [#2, 1033K] [#3,
48K] [#4, 45K] [#5,
152K] Related Slide Sets (pdf): [#1,
3490K] [#2, 1061K] [#3,
52K] [#4, 79K] [#5,
136K] |
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Major Outcomes in Moderately Hypercholesterolemic,
Hypertensive Patients Randomized to Pravastatin vs Usual Care: The
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
(ALLHAT).
|
 | The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group.
JAMA 2002; 288: 2998-3007. [PDF] Related Slide Set:
[PowerPoint, 695K] [PDF, 910K]
Table of Trials included in Weighted Meta-Regression
Lines in Figure 5 [PDF]
References for Figure 5
[PDF] |
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Diuretic versus α-blocker as first-step
antihypertensive therapy. Final results from the Antihypertensive and
Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
|
 | ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group.
Hypertension 2003; 42:239-246 [PDF] Related Slide Set:
[PowerPoint, 1635K] [PDF, 329K] |
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Clinical Events in High-Risk Hypertensive Patients Randomly
Assigned to Calcium Channel Blocker Versus Angiotensin-Converting Enzyme
Inhibitor in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart
Attack Trial
|
 | Frans H.H. Leenen, Chuke E. Nwachuku, Henry R. Black, William C. Cushman,
Barry R. Davis, Lara M. Simpson, Michael H. Alderman, Steven A. Atlas, Jan N. Basile, Aloysius B. Cuyjet,
Richard Dart, James V. Felicetta, Richard H. Grimm, L. Julian Haywood, Syed Z.A. Jafri, Michael A. Proschan,
Udho Thadani, Paul K. Whelton, Jackson T. Wright Hypertension 2006; 48;374-384 [PDF] |
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Other
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Experimental approaches to determining the choice of first
step therapy for patients with hypertension.
|
 | Whelton PK, Williamson JD, Louis GT, Davis BR, Cutler JA, for the ALLHAT Research Group.
Clinical and Experimental Hypertension 1996; 18:569-579 [PDF] |
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Operational aspects of terminating the doxazosin arm of the
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
(ALLHAT)
|
 | Pressel SL, Davis BR, Wright JT, Geraci TS, Kingry C, Ford CE, Piller LB, Bettencourt J, Kimmel B, Lusk C, Parks H, Simpson LM, Nwachuku C, Furberg CD, for the ALLHAT Collaborative Research Group.
Controlled Clinical Trials 2001; 22:29-41 [PDF] |
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The ALLHAT Adherence Survival Kit.
|
 | Applied Clinical Trials 2004; 13:40-48 [PDF] |
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Incidence and Predictors of Angioedema in Elderly
Hypertensive Patients at High Risk for Cardiovascular Disease: A Report from
the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
(ALLHAT).
|
 | Piller LB, Ford CE, Davis BR, Nwachuku CE, Black HR, Oparil S, Retta TM, Probstfield JL.
Journal of Clinical Hypertension 2006:8(9);649-56, CME quiz 657-8. [PDF]
Related Slide Set: [PowerPoint,
618K] [PDF, 207K]
[Link
to the article] |
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Management of High Blood Pressure in Clinical Practice:
Perceptible Qualitative Differences in Approaches Utilized by Clinicians.
|
 | Nwachuku CE, Bastien A, Cutler JA, Grob GM, Margolis KL, Rocella EJ, Pressel S, Davis BR, Caso M, Sheps S, Weber M.
Journal of Clinical Hypertension 2008:10;822-829. [PDF]
[Link
to the article]
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Thiazide-type diuretics and beta-adrenergic blockers as
first-line drug treatments for hypertension.
|
 | Cutler JA. Davis BR. Circulation. 2008;117:2691-704; discussion 2705 |
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Outcomes in Demographic Subgroups
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Outcomes in hypertensive black and nonblack patients treated
with chlorthalidone, amlodipine, and lisinopril.
|
 | Wright JT, Dunn JK, Cutler JA, Davis BR, Cushman WC, Ford CE, Haywood LJ, Leenen FHH, Margolis KL, Papademetriou V, Probstfield JL, Whelton PK, Habib GB, for the ALLHAT Collaborative Research Group.
JAMA 2005; 293:1595-1608 [PDF]
Related Slide Set: [PowerPoint, 589K] [PDF,204K] |
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Recruitment
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The Antihypertensive and Lipid-Lowering Treatment to Prevent
Heart Attack Trial (ALLHAT): Clinical center recruitment experience.
|
 | Wright JT, Jr, Cushman WC, Davis BR, Barzilay J, Colon P, Egan D, Lucente T, Nwachuku C, Pressel S, Leenen FHH, Frolkis J, Letterer R, Walsh S, Tobin JN, Deger GE, for the ALLHAT Research Group.
Controlled Clinical Trials 2001; 22:659-673 [PDF]
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Participant Recruitment in the Antihypertensive and
Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
|
 | Pressel S, Davis BR, Louis GT, Whelton P, Adrogue H, Egan D, Farber M, Payne G, Probstfield J, and Ward H for the ALLHAT Research Group.
Controlled Clinical Trials 2001;22:674-686
[PDF]
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Renal Status and Outcomes
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The prevalence of reduced glomerular filtration rate in
older hypertensive patients and its association with cardiovascular disease: a
report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart
Attack Trial.
|
 | Rahman M, Brown CD, Coresh J, Davis BR, Eckfeldt JH, Kopyt N, Levey AS, Nwachuku C, Pressel S, Reisin E, Walworth C for the ALLHAT Collaborative Research Group.
Arch Intern Med. 2004;164:969-976.
[PDF]
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Cardiovascular outcomes in high-risk hypertensive patients
stratified by baseline glomerular filtration rate.
|
 | Rahman M, Pressel S, Davis B, Nwachuku C, Wright JT Jr., Whelton PK, Barzilay J, Batuman V, Eckfeldt JH, Farber MA, Franklin S, Henriquez M, Kopyt N, Louis GT, Saklayen M, Stanford C, Walworth C, Ward M, Weigmann T for the ALLHAT Collaborative Research Group.
Ann Intern Med. 2006; 144:172-180.
[PDF]
Related Slide Set 1: [PowerPoint, 327K] [PDF, 94K] |
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Renal outcomes in hypertensive patients with impaired renal
function.
|
 | Rahman M, Cutler J, Davis B, Pressel S, Whelton P, for the ALLHAT Collaborative Research Group.
Archives of Internal Medicine 2005;165:936-946 [PDF]
Related Slide Set 1: [PowerPoint, 346K] [PDF, 129K] |
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Progression of kidney disease in moderately
hypercholesterolemic, hypertensive patients randomized to pravastatin versus
usual care: a report from the Antihypertensive and Lipid-Lowering Treatment to
Prevent Heart Attack Trial (ALLHAT).
|
 | Rahman M, Baimbridge C, Davis BR, Barzilay J, Basile JN, Henriquez MA, Huml A, Kopyt N, Louis GT,
Pressel SL, Rosendorff C, Sastrasinh S, Stanford C; ALLHAT Collaborative Research Group.
Am J Kidney Dis. 2008;52:412-24 Comment in: Am J Kidney Dis. 2008;52:391-4.
[PDF]
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